The fungal metabolite brefeldin A inhibits Dvl2-Plk1-dependent primary cilium disassembly

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Title
The fungal metabolite brefeldin A inhibits Dvl2-Plk1-dependent primary cilium disassembly
Author(s)
Uijeong Lee; Sun Ok Kim; Jeong Ah Hwang; Jae-Hyuk Jang; Sangkeun Son; In Ja RyooJong Seog AhnBo Yeon KimKyung Ho Lee
Bibliographic Citation
Molecules and Cells, vol. 40, no. 6, pp. 401-409
Publication Year
2017
Abstract
The primary cilium is a non-motile microtubule-based organelle that protrudes from the surface of most human cells and works as a cellular antenna to accept extracellular signals. Primary cilia assemble from the basal body during the resting stage (G0 phase) and simultaneously disassemble with cell cycle re-entry. Defective control of assembly or disassembly causes diverse human diseases including ciliopathy and cancer. To identify the effective compounds for studying primary cilium disassembly, we have screened 297 natural compounds and identified 18 and 17 primary cilium assembly and disassembly inhibitors, respectively. Among them, the application of KY-0120, identified as Brefeldin A, disturbed Dvl2- Plk1-mediated cilium disassembly via repression of the interaction of CK1ε-Dvl2 and the expression of Plk1 mRNA. Therefore, our study may suggest useful compounds for studying the cellular mechanism of primary cilium disassembly to prevent ciliopathy and cancer
Keyword
Brefeldin ADvl2InhibitorPlk1Primary cilium disassembly
ISSN
1016-8478
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.14348/molcells.2017.0032
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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