Acyclic triterpenoids from Alpinia katsumadai inhibit IL-6-Induced STAT3 activation

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Title
Acyclic triterpenoids from Alpinia katsumadai inhibit IL-6-Induced STAT3 activation
Author(s)
Hyun Jae JangSeung Jae LeeSoyoung LeeKyungsook JungSeung Woong LeeMun Chual Rho
Bibliographic Citation
Molecules, vol. 22, no. 10, pp. 1611-1611
Publication Year
2017
Abstract
The seeds of Alpinia katsumadai yielded two new acyclic triterpenoids, 2,3,6,22,23 -pentahydroxy -2,6,11,15,19,23-hexamethyl-tetracosa-7,10,14,18-tetraene (3) and 2,3,6,22,23 -pentahydroxy-2,10,15,19,23-hexamethyl-7-methylenetetracosa-10,14,18-triene (4), as well as two known compounds, 2,3,22,23-tertrahydroxy-2,6,10,15,19,23-hexamethyl-tetracosa-6,10,14,18-tetraene (1) and 2,3,5,22,23-pentahydroxy-2,6,10,15,19,23-hexamethyl-tetracosa-6,10,14,18-tetraene (2). The absolute configurations of 2 and 3, which were determined by means of a modified Mosher’s method, are suggested as (3R; 5S; 22R) and (3R; 22R), respectively. Compounds 1?4 inhibited IL-6-induced JAK2/STAT3 activity in a dose-dependent fashion, with IC50 values of 0.67, 0.71, 2.18, and 2.99 μM. Moreover, IL-6-stimulated phosphorylation of STAT3 was significantly suppressed in U266 cells by the administration of A. katsumadai EtOH extract and Compounds 1 and 2. These results suggest that major phytochemicals, Compounds 1 and 2, obtained from A. katsumadai may be useful candidates for designing new IL-6 inhibitors as anti-inflammatory agents
Keyword
Acyclic triterpenoidsAlpinia katsumadaiIL-6InflammationSTAT3
ISSN
1420-3049
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/molecules22101611
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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