New neo-lignan from Acanthopanax senticosus with protein tyrosine phosphatase 1B inhibitory activity
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- Title
- New neo-lignan from Acanthopanax senticosus with protein tyrosine phosphatase 1B inhibitory activity
- Author(s)
- J L Li; N Li; S S Xing; N Zhang; B B Li; J G Chen; Jong Seog Ahn; L Cui
- Bibliographic Citation
- Archives of Pharmacal Research, vol. 40, no. 11, pp. 1265-1270
- Publication Year
- 2017
- Abstract
- New neo-lignan, (7S, 8R)-3-hydroxyl-4-methoxyl-balanophonin (1), together with seven known compounds (2？8) were isolated from the EtOAc-soluble extract of Acanthopanax senticosus. The structure of the new neo-lignan was elucidated with spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against PTP1B, VHR and PP1. Among them, the new compound (1) was found to exhibit selective inhibitory activity on PTP1B with IC 50 value 15.2 ± 1.4 μM. ⓒ 2015, The Pharmaceutical Society of Korea.
- ISSN
- 0253-6269
- Publisher
- Pharmaceutical Soc Korea
- Full Text Link
- http://dx.doi.org/10.1007/s12272-015-0659-7
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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