Anti-inflammatory effect of lactic acid bacteria isolated from kimchi on acid-induced acute colitis in model mice

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Title
Anti-inflammatory effect of lactic acid bacteria isolated from kimchi on acid-induced acute colitis in model mice
Author(s)
S Y Lee; S S Sekhon; Hyung Cheol Kim; K Won; J Y Ahn; K Lee; Y H Kim
Bibliographic Citation
Toxicology and Environmental Health Sciences, vol. 9, no. 5, pp. 279-283
Publication Year
2017
Abstract
Lactic acid bacteria (LAB) provide numerous beneficial effects on the host body, especially on the intestine. Two LAB strains isolated from Kimchi, Leuconostoc mesenteroides and Lactobacillus sakei, were studied for its anti-inflammatory activity in acidinduced acute colitis in mice. To induce acute colitis in model mice (C57BL/6), 3% of dextran sulfate sodium treatment was treated for 7 days. Assessment of necropsy and histopathology analysis showed that oral supplementation of both L. mesenteroides and L. sakei ameliorated the symptoms of acute colitis. Moreover, the mixture of L. meseneroides and L. sakei showed synergistic effect on colitis. The results suggest that the formulation of L. mesenteroides and L. sakei mixture could be used as an oral supplementation to decrease the inflammatory harmful environment associated with colitis
Keyword
Anti-inflammationColitisLactic acid bacteriaOral supplementation
ISSN
2005-9752
Publisher
Springer Verlag (Germany)
DOI
http://dx.doi.org/10.1007/s13530-017-0332-2
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > Technology Transfer Center > 1. Journal Articles
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