Eucalyptus globulus inhibits inflammasome-activated pro-inflammatory responses and ameliorate monosodium urate-induced peritonitis in murine experimental model

Cited 6 time in scopus
Metadata Downloads
Title
Eucalyptus globulus inhibits inflammasome-activated pro-inflammatory responses and ameliorate monosodium urate-induced peritonitis in murine experimental model
Author(s)
Y E Ji; X Sun; M K Kim; W Y Li; Sang Woo Lee; S Koppula; S H Yu; H B Kim; T B Kang; K H Lee
Bibliographic Citation
American Journal of Chinese Medicine, vol. 46, no. 2, pp. 423-433
Publication Year
2018
Abstract
Eucalyptus globulus Labill. (E. globulus, Myrtaceae) is used in Europe as a traditional folk remedy for inflammation-related disorders such as arthritis, diabetes, asthma, and gout. We investigated this study to evaluate the protective effects of E. globulus extract (EG) on inflammatory responses, and provide scientific and mechanistic evidence in in vitro and in vivo experimental models. LPS-stimulated murine bone marrow-derived macrophages (BMDMs) were used to study the regulatory effect of EG on inflammasome activation in vitro. Monosodium urate (MSU)-induced peritonitis was used to study the effect of EG in an in vivo murine model. EG suppressed IL-1β secretion via the regulation of apoptosis-associated speck-like proteins containing a CARD (ASC) oligomerization and caspase-1 maturation, leading to the inhibition of inflammasome activation. In the in vivo study, EG suppressed the MSU-induced peritonitis by attenuating interleukin (IL)-1β, providing scientific support for its traditional use in the treatment of inflammation-related disorders.
Keyword
ASCEucalyptus globulus LabillInflammasomePeritonitis
ISSN
0192-415X
Publisher
World Scientific Publ Co Pte Ltd
DOI
http://dx.doi.org/10.1142/S0192415X18500210
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > International Biological Material Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.