Bioactive α-pyrone derivatives from the endolichenic fungus Dothideomycetes sp. EL003334 = 지의류 내생 곰팡이로부터 분리한 신규물질

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Title
Bioactive α-pyrone derivatives from the endolichenic fungus Dothideomycetes sp. EL003334 = 지의류 내생 곰팡이로부터 분리한 신규물질
Author(s)
Gil Su Kim; W Ko; Jong Won Kim; M H Jeong; Sung-Kyun Ko; J S Hur; H Oh; Jae-Hyuk JangJong Seog Ahn
Bibliographic Citation
Journal of Natural Products, vol. 81, no. 4, pp. 1084-1088
Publication Year
2018
Abstract
Two new α-pyrones, dothideopyrones E (1) and F (2), were isolated from a culture of the endolichenic fungus Dothideomycetes sp. EL003334. Their structures were elucidated by spectroscopic data analysis. Their absolute configurations were established by the modified Mosher's method. Compound 2 inhibited nitric oxide (NO) production with IC50 values of 15.0 ± 2.8 μM in lipopolysaccharide (LPS)-induced BV2 cells. Compound 2 diminished the protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, 2 decreased the mRNA expression levels of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/acs.jnatprod.7b01022
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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