Genkwalathins A and B, new lathyrane-type diterpenes from Daphne genkwa

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Title
Genkwalathins A and B, new lathyrane-type diterpenes from Daphne genkwa
Author(s)
N V Minh; Baek Soo Han; Ha Young Choi; Jeong Su Byun; Ji Su Park; Won Gon Kim
Bibliographic Citation
Natural Product Research, vol. 32, no. 15, pp. 1782-1790
Publication Year
2018
Abstract
Screening for new natural anti-neuroinflammatory compounds was performed with the traditional folk medicine Genkwa Flos, which potently inhibited nitric oxide (NO) production by LPS-activated microglial BV-2 cells. Two new lathyrane-type diterpenes, genkwalathins A (1) and B (2), and 14 known daphnane-type diterpenes (3?16) were isolated. The lathyrane-type diterpenes were isolated for the first time from the Thymelaeaceae family in this study. Compounds 1 and 2 moderately inhibited LPS-induced NO production in BV-2 cells without affecting cell viability, while six daphnane-type diterpenes (3, 4, 6, 7, 9 and 10) potently reduced NO production with IC50 values less than 1 μM, although they did display weak cytotoxicity. A structure?activity relationship study on the daphnane-type diterpenes indicated that the stereochemistry at C-19, the benzoate group at C-20, and the epoxide moiety could be important for their anti-neuroinflammatory effects.
Keyword
anti-neuroinflammatorydaphnane-type diterpeneDaphne genkwaGenkwa Floslathyrane-type diterpene
ISSN
1029-2349
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.1080/14786419.2017.1402322
Type
Article
Appears in Collections:
Division of Research on National Challenges > Biodefense Research Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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