Four new flavonoids with DGAT inhibitory activity from Psoralea corylifolia

Abstract

Four new compounds, 3′'-methoxy-bavacoumestan C (1), 6,7-furanbavachinone B (2), 3,4- furanbavachalcone A (3) and 4,5- furanbavachalcone A (4), together with seven known flavonoids were isolated from the Psoralea corylifolia. Their structures were determined by extensive spectroscopic and physicochemical analyses. All the compounds (1？11) were evaluated for in vitro inhibitory activity against DGAT. Among them, compounds 1, 6, 7, 10 and 11 were found to exhibit selective inhibitory activity on DGAT1with IC50 values ranging from 78.5 ± 1.7 to 153.4 ± 1.5 μM.