Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition
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- Title
- Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition
- Author(s)
- Bo Yeon Kim; Ji Hee Yoon; M Kim; J N Kim; H Park; S E Ryu; Sangku Lee
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry Letters, vol. 29, no. 14, pp. 1746-1748
- Publication Year
- 2019
- Abstract
- Structure based virtual screening attempts to discover DUSP1 inhibitors have yielded a scaffold featuring benzoxazole and acylthiourea pharmacophore. A series of its analogues were synthesized to explore structure activity relationship (SAR) of DUSP1 inhibition.
- Keyword
- Mitogen-activated protein kinaseEnzyme inhibitionStructure activity relationshipCancerDual specificity phosphatase
- ISSN
- 0960-894X
- Publisher
- Elsevier
- Full Text Link
- http://dx.doi.org/10.1016/j.bmcl.2019.05.021
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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