Studies on antioxidant activity and in vitro inhibitory activity of tyrosinase and collagenase in Artocarpus nitidus subsp. lingnaensis (Merr.) F.M. Jarrett using 4 parameter logistic = 변수 분석을 통한 아토카푸스 니티두스 추출물과 분획물의 항산화, 타이로시나제 및 콜라제나제 In Vitro 저해활성 연구

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Title
Studies on antioxidant activity and in vitro inhibitory activity of tyrosinase and collagenase in Artocarpus nitidus subsp. lingnaensis (Merr.) F.M. Jarrett using 4 parameter logistic = 변수 분석을 통한 아토카푸스 니티두스 추출물과 분획물의 항산화, 타이로시나제 및 콜라제나제 In Vitro 저해활성 연구
Author(s)
Kwang-Hee Son; Young-Kook Kim; Sangho Choi; Z Zhang; D H Shin; J S Lee; Ho Yong Park
Bibliographic Citation
Journal of Society of Cosmetic Scientists of Korea, vol. 45, no. 2, pp. 161-173
Publication Year
2019
Abstract
In this study, the antioxidative and inhibitory activity of tyrosinase and collagenase for the solvent extract and silica column fractions of Artocarpus nitidus were evaluated. The activities were quantified using the 4 parameter logistic. LC/MS analysis showed that the major component of the fractions was polyphenol and the total polyphenol content of the extract was 48.1 ± 2.6 mg GAE/g. The radical scavenging activities (SC50) for 1,1-diphenyl-2-picrylhydrazyl of the extract, fraction-1 and fraction-2 were 16.7, 42.0 and 10.1 μg/mL, respectively. The value for fraction-2 was the closest to ascorbic acid (1.5 μg/mL). The tyrosinase inhibitory activity of the extracts and the fractions showed IC50 of 64.9, 0.9 and 1.2 μg/mL, respectively, and overall activity was higher than that of kojic acid (7.4 μg/mL) and arbutin (119.0 μg/mL). In the experiment by zebrafish embryo, the whitening activity of fraction-2 (27.5%) was higher than that of kojic acid (18.6%), and there was no adverse effect up to 500 μg/mL of fraction-2. For the collagenase inhibitory activity, the samples showed IC50 of 139.8, 20.6, and 16.8 μg/mL, respectively, which were competitive to 1, 10-Phenanthroline (55.4 μg/mL). The extract and fraction-2 showed IC50 of 61.8 and 67.1 μg/mL for elastase. These results suggest that A. nitidus extract can be used as a cosmetic material useful for antioxidant, whitening, and prevention of skin aging without adverse effects.
Keyword
antioxidantpolyphenolcollagenase inhibitiontyrosinase inhibitionArtocarpus nitidus
ISSN
1226-2587
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.15230/SCSK.2019.45.2.161
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > International Biological Material Research Center > 1. Journal Articles
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