Cited 2 time in
- Critical roles of E2f3 in Growth and musculo-skeletal phenotype in mice
- Hae-Rim Kim; Faiz Ur Rahman; Kwang Soo Kim; Eun-Kyeung Kim; Sang Mi Cho; Kihoon Lee; Ok Sung Moon; Young Won Seo; Won Kee Yoon; Young Suk Won; Hoyoung Kang; Hyoung-Chin Kim; Ki Hoan Nam
- Bibliographic Citation
- International Journal of Medical Sciences, vol. 16, no. 12, pp. 1557-1563
- Publication Year
- E2F3, a member of the E2F family, plays a critical role in cell cycle and proliferation by targeting downstream, retinoblastoma (RB) a tumor suppressor family protein. The purpose of this study, was to investigate the role and function of E2F3 in vivo. We examined phenotypic abnormalities, by deletion of the E2f3 gene in mice. Complete ablation of the E2F3 was fully penetrant, in the pure C57BL/6N background. The E2f3+/ - mouse embryo developed normally without fatal disorder. However, they exhibited reduced body weight, growth retardation, skeletal imperfection, and poor grip strength ability. Findings suggest that E2F3 has a pivotal role in muscle and bone development, and affect normal mouse growth.
- Development; E2f3+/- Knockout; Growth retardation; Mouse phenotype; skeletal imperfection
- Ivyspring Int Publ
- Appears in Collections:
- Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > 1. Journal Articles
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