Critical roles of E2f3 in Growth and musculo-skeletal phenotype in mice

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Title
Critical roles of E2f3 in Growth and musculo-skeletal phenotype in mice
Author(s)
Hae-Rim Kim; Faiz Ur Rahman; Kwang Soo Kim; Eun-Kyeung KimSang Mi ChoKihoon LeeOk Sung MoonYoung Won SeoWon Kee YoonYoung Suk WonHoyoung KangHyoung-Chin KimKi Hoan Nam
Bibliographic Citation
International Journal of Medical Sciences, vol. 16, no. 12, pp. 1557-1563
Publication Year
2019
Abstract
E2F3, a member of the E2F family, plays a critical role in cell cycle and proliferation by targeting downstream, retinoblastoma (RB) a tumor suppressor family protein. The purpose of this study, was to investigate the role and function of E2F3 in vivo. We examined phenotypic abnormalities, by deletion of the E2f3 gene in mice. Complete ablation of the E2F3 was fully penetrant, in the pure C57BL/6N background. The E2f3+/ - mouse embryo developed normally without fatal disorder. However, they exhibited reduced body weight, growth retardation, skeletal imperfection, and poor grip strength ability. Findings suggest that E2F3 has a pivotal role in muscle and bone development, and affect normal mouse growth.
Keyword
DevelopmentE2f3+/- KnockoutGrowth retardationMouse phenotypeskeletal imperfection
ISSN
1449-1907
Publisher
Ivyspring Int Publ
DOI
http://dx.doi.org/10.7150/ijms.39068
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > 1. Journal Articles
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