Suppression of DNCB-induced atopic skin lesions in mice by Wikstroemia indica extract

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dc.contributor.authorS Y Lee-
dc.contributor.authorN J Park-
dc.contributor.authorJ Jegal-
dc.contributor.authorB G Jo-
dc.contributor.authorSangho Choi-
dc.contributor.authorSang Woo Lee-
dc.contributor.authorM S Uddin-
dc.contributor.authorS N Kim-
dc.contributor.authorM H Yang-
dc.date.accessioned2020-02-07T16:31:03Z-
dc.date.available2020-02-07T16:31:03Z-
dc.date.issued2020-
dc.identifier.issn20726643-
dc.identifier.uri10.3390/nu12010173ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/19282-
dc.description.abstractWikstroemia indica (L.) C.A. Mey. is used in traditional Chinese medicine to treat inflammatory diseases such as arthritis and bronchitis. In this study, we aimed to investigate the effects of an ethanolic extract of W. indica on cutaneous inflammation in mice with 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD). Dermal administration of W. indica ethanolic extract to DNCB-sensitized hairless mice with dermatitis, for two weeks, reduced erythema, scaling, and edema. Skin hydration was improved and transepidermal water loss was reduced at a W. indica concentration of 1%. Furthermore, W. indica also significantly reduced serum IgE and IL-4 concentrations in our mouse model. These results suggest that W. indica has potential as a topical treatment for AD and as an adjunctive agent to control AD.-
dc.publisherMDPI-
dc.titleSuppression of DNCB-induced atopic skin lesions in mice by Wikstroemia indica extract-
dc.title.alternativeSuppression of DNCB-induced atopic skin lesions in mice by Wikstroemia indica extract-
dc.typeArticle-
dc.citation.titleNutrients-
dc.citation.number0-
dc.citation.endPage173-
dc.citation.startPage173-
dc.citation.volume12-
dc.contributor.affiliatedAuthorSangho Choi-
dc.contributor.affiliatedAuthorSang Woo Lee-
dc.contributor.alternativeName이소연-
dc.contributor.alternativeName박노준-
dc.contributor.alternativeName제갈종환-
dc.contributor.alternativeName조범근-
dc.contributor.alternativeName최상호-
dc.contributor.alternativeName이상우-
dc.contributor.alternativeNameUddin-
dc.contributor.alternativeName김수남-
dc.contributor.alternativeName양민혜-
dc.identifier.bibliographicCitationNutrients, vol. 12, pp. 173-173-
dc.identifier.doi10.3390/nu12010173-
dc.subject.keyword2,4-dinitrochlorobenzene-
dc.subject.keywordWikstroemia indica-
dc.subject.keywordatopic dermatitis-
dc.subject.keywordinterleukin-
dc.subject.keywordtransepidermal water loss-
dc.subject.local2,4-dinitrochlorobenzene-
dc.subject.local2,4-Dinitrochlorobenzene-
dc.subject.localWikstroemia indica-
dc.subject.localatopic dermatitis-
dc.subject.localAtopic dermatitis-
dc.subject.localinterleukin-
dc.subject.localtransepidermal water loss-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > International Biological Material Research Center > 1. Journal Articles
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