Suppression of DNCB-induced atopic skin lesions in mice by Wikstroemia indica extract

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Title
Suppression of DNCB-induced atopic skin lesions in mice by Wikstroemia indica extract
Author(s)
S Y Lee; N J Park; J Jegal; B G Jo; Sangho ChoiSang Woo Lee; M S Uddin; S N Kim; M H Yang
Bibliographic Citation
Nutrients, vol. 12, pp. 173-173
Publication Year
2020
Abstract
Wikstroemia indica (L.) C.A. Mey. is used in traditional Chinese medicine to treat inflammatory diseases such as arthritis and bronchitis. In this study, we aimed to investigate the effects of an ethanolic extract of W. indica on cutaneous inflammation in mice with 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD). Dermal administration of W. indica ethanolic extract to DNCB-sensitized hairless mice with dermatitis, for two weeks, reduced erythema, scaling, and edema. Skin hydration was improved and transepidermal water loss was reduced at a W. indica concentration of 1%. Furthermore, W. indica also significantly reduced serum IgE and IL-4 concentrations in our mouse model. These results suggest that W. indica has potential as a topical treatment for AD and as an adjunctive agent to control AD.
Keyword
2,4-dinitrochlorobenzeneWikstroemia indicaatopic dermatitisinterleukintransepidermal water loss
ISSN
2072-6643
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/nu12010173
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > International Biological Material Research Center > 1. Journal Articles
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