Metabolomics approach to identify the active substances influencing the antidiabetic activity of Lagerstroemia species = Lagerstroemia 종의 항당뇨 활성에 영향을 미치는 활성성분을 판별하기위한 대사체학 접근

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Title
Metabolomics approach to identify the active substances influencing the antidiabetic activity of Lagerstroemia species = Lagerstroemia 종의 항당뇨 활성에 영향을 미치는 활성성분을 판별하기위한 대사체학 접근
Author(s)
Mun-Ock KimSu Ui Lee; H J Yuk; Hyun Jae JangJae Won Lee; Eunbin Kwon; Jin Hyub PaikSangho Choi; A Nizar; T T Bach; K Sydara; H Jin; Woo So Yeun; Sei-Ryang OhHyung Won Ryu
Bibliographic Citation
Journal of Functional Foods, vol. 64, pp. 103684-103684
Publication Year
2020
Abstract
Rational and efficient approaches to research and development are becoming more popular for increasing value enhancement in bioactive materials. In this study, metabolite profiles of 17 different Lagerstroemia species from different countries were performed using UPLC-QTof-MS combined with chemometric tools to identify potential metabolite predictors of antidiabetic activity. PLS-DA of the Lagerstroemia samples indicated two large, distinct clusters in the score plot. On the loading scatter plot, significant changes in metabolites of antidiabetic candidates were found between species, and two flavonol glycosides and corosolic acid were evaluated as key markers among the 25 analyzed metabolites. Based on the screening results, samples high in two triterpenic acids (corosolic acid and asiatic acid) showed a tendency to inhibit glucose uptake, which could have contributed to the correlation of active and inactive extracts. Therefore, these comprehensive results support our biochemometric models and contribute to the rational and efficient studies of pharmacologically active metabolites.
Keyword
AntidiabeticCorosolic acidFlavonol glycosidesLagerstroemiaMetabolomics
ISSN
1756-4646
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.jff.2019.103684
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > International Biological Material Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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