2-하이드록시-아릴아미드 유도체 또는 이의 약학적으로 허용가능한염, 이의제조방법및이를유효성분으로 함유하는암예방또는치료용약학적조성물

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Title
2-하이드록시-아릴아미드 유도체 또는 이의 약학적으로 허용가능한염, 이의제조방법및이를유효성분으로 함유하는암예방또는치료용약학적조성물
Alternative Title
2-hydroxy-arylamide derivatives or pharmaceutically acceptable salts thereof, process for the preparation thereof, and pharmaceutical composition for the prevention and treatment of cancers containing the same as an active ingredient
Inventor(s)
김세미; 고동준; 남은희; 민혜진
Assignee(s)
한국생명공학연구원
Application No.
14/256,808 (2014.04.18)
Registration No.
9,266,872 (2016.02.23)
Country
미국
Abstract
The present invention relates to a 2-hydroxyarylamide derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient. The 2-hydroxyarylamide derivative prepared by the present invention is excellent in the inhibition of the activity of TMPRSS4 serine protease and the suppression of the infiltration of TMPRSS4-expressed cancer cells, and thus can be useful as a composition for preventing or treating cancer by inhibiting TMPRSS4 over-expressed in cancer cells, particularly, colorectal cancer, lung cancer, breast cancer, prostate cancer, ovarian cancer, pancreatic cancer, or stomach cancer cells.
Type
Patent
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 2. Patents
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