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- Title
- 2-하이드록시-아릴아미드 유도체 또는 이의 약학적으로 허용가능한염, 이의제조방법및이를유효성분으로 함유하는암예방또는치료용약학적조성물
- Alternative Title
- 2-hydroxy-arylamide derivatives or pharmaceutically acceptable salts thereof, process for the preparation thereof, and pharmaceutical composition for the prevention and treatment of cancers containing the same as an active ingredient
- Inventor(s)
- 김세미; 고동준; 남은희; 민혜진
- Assignee(s)
- 한국생명공학연구원
- Application No.
- 14/256,808 (2014.04.18)
- Registration No.
- 9,266,872 (2016.02.23)
- Country
- 미국
- Abstract
- The present invention relates to a 2-hydroxyarylamide derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient. The 2-hydroxyarylamide derivative prepared by the present invention is excellent in the inhibition of the activity of TMPRSS4 serine protease and the suppression of the infiltration of TMPRSS4-expressed cancer cells, and thus can be useful as a composition for preventing or treating cancer by inhibiting TMPRSS4 over-expressed in cancer cells, particularly, colorectal cancer, lung cancer, breast cancer, prostate cancer, ovarian cancer, pancreatic cancer, or stomach cancer cells.
- Type
- Patent
- Appears in Collections:
- Division of Biomedical Research > Microbiome Convergence Research Center > 2. Patents
- Files in This Item:
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