Effect of heat-killed Enterococcus faecalis EF-2001 on ethanol-induced acute gastric injury in mice: protective effect of EF-2001 on acute gastric ulcer

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Title
Effect of heat-killed Enterococcus faecalis EF-2001 on ethanol-induced acute gastric injury in mice: protective effect of EF-2001 on acute gastric ulcer
Author(s)
D B Jeon; H G Shin; B W Lee; S H Jeong; J H Kim; J H Ha; J Y Park; H J Kwon; W J Kim; Young Bae RyuIn Chul Lee
Bibliographic Citation
Human & Experimental Toxicology, vol. 39, no. 5, pp. 721-733
Publication Year
2020
Abstract
Enterococcus faecalis is a facultative anaerobic gram-positive commensal bacterium common in the gastrointestinal tract of animals and humans. This study aimed to investigate the protective effects of heat-killed E. faecalis EF-2001 (EF-2001) on acute gastric ulcer using a murine model of ethanol (EtOH)-induced acute gastric injury. EF-2001 (20, 40, and 80 mg/kg/day) was administered by oral gavage for 5 days before EtOH treatment (10 mL/kg body weight). EF-2001 effectively attenuated EtOH-induced gastric mucosal injury with reduced gastric mucosal ulcer and histological damage score. Pretreatment of EF-2001 markedly suppressed the phosphorylation of mitogen-activated protein kinases (MAPKs; ERK1/2, JNK, and p38MAPK). In addition, EF-2001 significantly inhibited phosphorylation of nuclear factor kappa B (NF-κB) and subsequently suppressed the upregulation of inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6 in gastric tissues. Taken together, these results suggest that EF-2001 exerts a gastroprotective effect against acute gastric injury, and the underlying mechanism might be associated with the suppression of MAPKs and NF-κB signaling and consequent reduction of pro-inflammatory mediators or cytokines.
Keyword
acute gastric ulceranti-inflammatory activityEnterococcus faecalis EF-2001EthanolMAPK/NF-κB pathway
ISSN
0960-3271
Publisher
Sage
DOI
http://dx.doi.org/10.1177/0960327119899987
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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