Croton hirtus L'Her extract prevents inflammation in RAW264.7 macrophages via inhibition of NF-κB signaling pathway

Cited 7 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorM J Kim-
dc.contributor.authorJ G Kim-
dc.contributor.authorK M Sydara-
dc.contributor.authorSang Woo Lee-
dc.contributor.authorS K Jung-
dc.date.accessioned2020-09-24T03:02:04Z-
dc.date.available2020-09-24T03:02:04Z-
dc.date.issued2020-
dc.identifier.issn10177825-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/22618-
dc.description.abstractConsumption of anti-inflammatory nutraceuticals may help treat or prevent inflammation-related illnesses such as diabetes, cardiovascular disease, and cancer. This study evaluated the effect of Croton hirtus L'Her extract (CHE) on lipopolysaccharide (LPS)-induced nitric oxide (NO) production and nuclear factor kappa-B (NF-κB) signaling cascades. CHE significantly suppressed LPS-induced NO production and inducible nitric oxide synthase (iNOS) expression in RAW264.7 macrophages, although cyclooxygenase (COX)-2 expression was not affected. CHE also suppressed LPS-induced IκB kinase (IKK), IκB, and p65 phosphorylation in RAW264.7 cells. Western blot and immunofluorescence assays of cytosol and nuclear p65 and the catalytic subunit of NF-κB showed that CHE suppressed LPS-induced p65 translocation from the cytosol to the nucleus. CHE also suppressed LPS-induced Interleukin (IL)-6 and tumor necrosis factor (TNF)-α production in RAW264.7 cells. These results suggest that CHE prevents NO-mediated inflammation by suppressing NF-κB and inflammatory cytokines.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleCroton hirtus L'Her extract prevents inflammation in RAW264.7 macrophages via inhibition of NF-κB signaling pathway-
dc.title.alternativeCroton hirtus L'Her extract prevents inflammation in RAW264.7 macrophages via inhibition of NF-κB signaling pathway-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number4-
dc.citation.endPage496-
dc.citation.startPage490-
dc.citation.volume30-
dc.contributor.affiliatedAuthorSang Woo Lee-
dc.contributor.alternativeName김민정-
dc.contributor.alternativeName김주경-
dc.contributor.alternativeNameSydara-
dc.contributor.alternativeName이상우-
dc.contributor.alternativeName정성근-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 30, no. 4, pp. 490-496-
dc.identifier.doi10.4014/JMB.1908.08045-
dc.subject.keywordCroton hirtus L'Her-
dc.subject.keywordInflammation-
dc.subject.keywordMacrophage-
dc.subject.keywordNF-κB-
dc.subject.keywordNitric oxide-
dc.subject.keywordNutraceuticals-
dc.subject.localCroton hirtus L'Her-
dc.subject.localInflammation-
dc.subject.localMacrophage-
dc.subject.localNF-κB-
dc.subject.localNF-kB-
dc.subject.localNitric oxide-
dc.subject.localNitric oxide (NO)-
dc.subject.localNutraceuticals-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > International Biological Material Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.