Cytoplasmic MYC is an anti-necroptotic protein

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Title
Cytoplasmic MYC is an anti-necroptotic protein
Author(s)
Eun-Woo Lee; D Seong; J Song
Bibliographic Citation
Molecular & Cellular Oncology, vol. 7, no. 6, pp. e1817697-e1817697
Publication Year
2020
Abstract
Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a pivotal factor in inducing necroptosis. Mechanistically, cytoplasmic MYC directly binds to RIPK3, inhibiting initial necrosome complex formation.
Keyword
MYCRIPK1RIPK3necroptosisTNF
ISSN
2372-3556
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.1080/23723556.2020.1817697
Type
Article
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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