Open Access@KRIBBDivision of Biomedical ResearchMetabolic Regulation Research Center1. Journal Articles
Cytoplasmic MYC is an anti-necroptotic protein
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- Title
- Cytoplasmic MYC is an anti-necroptotic protein
- Author(s)
- Eun-Woo Lee; D Seong; J Song
- Bibliographic Citation
- Molecular & Cellular Oncology, vol. 7, no. 6, pp. e1817697-e1817697
- Publication Year
- 2020
- Abstract
- Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a pivotal factor in inducing necroptosis. Mechanistically, cytoplasmic MYC directly binds to RIPK3, inhibiting initial necrosome complex formation.
- Keyword
- MYCRIPK1RIPK3necroptosisTNF
- ISSN
- 2372-3556
- Publisher
- T&F (Taylor & Francis)
- Type
- Article
- Appears in Collections:
- Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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