Sargassum horneri as a functional food ameliorated IgE/BSA-induced mast cell activation and passive cutaneous anaphylaxis in mice

Cited 2 time in scopus
Metadata Downloads
Title
Sargassum horneri as a functional food ameliorated IgE/BSA-induced mast cell activation and passive cutaneous anaphylaxis in mice
Author(s)
E J Han; H S Kim; K K A Sanjeewa; Kyungsook Jung; Y Jee; Y J Jeon; I P S Fernando; G Ahn
Bibliographic Citation
Marine Drugs, vol. 18, no. 12, pp. 594-594
Publication Year
2020
Abstract
Sargassum horneri (S. horneri), an edible brown alga, has been proposed as a functional food with an improvement effect on abnormal skin immune responses. The present study investigates the anti-allergic effect of an ethanol extract from S. horneri (SHE) on immunoglobulin E (IgE)/bovine serum albumin (BSA)-mediated activation in bone marrow-derived cultured-mast cells (BMCMCs) and passive cutaneous anaphylaxis (PCA) reaction in mice. SHE markedly and dose-dependently suppressed the degranulation of BMCMCs by reducing the β-hexosaminidase and histamine release without cytotoxicity. In addition, SHE significantly decreased the FcεRI expression on the surface of BMCMCs and its IgE binding. Moreover, SHE reduced the mRNA expression and the production of allergic cytokines; interleukin (IL)-1β, IL-4, IL-5, IL-6, IL-10, IL-13; interferon (IFN)-γ and/or tumor necrosis factor (TNF)-α; and a chemokine, thymus and activation-regulated chemokine (TARC), by suppressing the activation of Src-family kinases and nuclear factor (NF)-κB signaling. In further study, the application of SHE reduced the PCA reaction in an IgE/BSA-induced type I allergic mice model. Taken together, we suggest that SHE has an anti-allergic effect in type I allergic responses.
Keyword
Sargassum horneribone marrow-derived cultured-mast cells (BMCMCs)immunoglobulinepassive cutaneous anaphylaxis (PCA)anti-allergic effect
ISSN
1660-3397
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/md18120594
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.