A pipecolic acid-rich branched cyclic depsipeptide ulleungamide C from a Streptomyces species induces G0/G1 cell cycle arrest in promyelocytic leukemia cells

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dc.contributor.authorSangkeun Son-
dc.contributor.authorMina Jang-
dc.contributor.authorByeongsan Lee-
dc.contributor.authorJun-Pil Jang-
dc.contributor.authorYoung-Soo Hong-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorSung-Kyun Ko-
dc.contributor.authorJae-Hyuk Jang-
dc.contributor.authorJong Seog Ahn-
dc.date.accessioned2021-02-20T03:30:57Z-
dc.date.available2021-02-20T03:30:57Z-
dc.date.issued2021-
dc.identifier.issn00218820-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24109-
dc.description.abstractIn this study, screening by LC-MS and cytotoxicity-guided isolation led to the identification of ulleungamide C (1), a previously unknown pipecolic acid-rich branched cyclic depsipeptide, from a soil actinobacterium Streptomyces sp. KCB13F003. The structure of 1 was determined by interpretation of spectroscopic and spectrometric data from 1D and 2D NMR and HRESIMS experiments. Antiproliferative assays using mammalian cancerous cells revealed that 1 inhibits the proliferation of HL-60 human promyelocytic leukemia cells. Cell cycle analysis showed an increased accumulation of cells in the G0/G1 phase after treatment with 1. Results of immunoblotting assays revealed that 1 reduced the expression levels of cyclin-dependent kinase 4 (CDK4), CDK6, retinoblastoma protein (Rb), and phosphorylated Rb, whereas it induced cyclin-dependent kinase inhibitor 1B (p27/Kip1) expression.-
dc.publisherSpringer-Nature Pub Group-
dc.titleA pipecolic acid-rich branched cyclic depsipeptide ulleungamide C from a Streptomyces species induces G0/G1 cell cycle arrest in promyelocytic leukemia cells-
dc.title.alternativeA pipecolic acid-rich branched cyclic depsipeptide ulleungamide C from a Streptomyces species induces G0/G1 cell cycle arrest in promyelocytic leukemia cells-
dc.typeArticle-
dc.citation.titleJournal of Antibiotics-
dc.citation.number3-
dc.citation.endPage189-
dc.citation.startPage181-
dc.citation.volume74-
dc.contributor.affiliatedAuthorSangkeun Son-
dc.contributor.affiliatedAuthorMina Jang-
dc.contributor.affiliatedAuthorByeongsan Lee-
dc.contributor.affiliatedAuthorJun-Pil Jang-
dc.contributor.affiliatedAuthorYoung-Soo Hong-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorSung-Kyun Ko-
dc.contributor.affiliatedAuthorJae-Hyuk Jang-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName손상근-
dc.contributor.alternativeName장민아-
dc.contributor.alternativeName이병산-
dc.contributor.alternativeName장준필-
dc.contributor.alternativeName홍영수-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName고성균-
dc.contributor.alternativeName장재혁-
dc.contributor.alternativeName안종석-
dc.identifier.bibliographicCitationJournal of Antibiotics, vol. 74, no. 3, pp. 181-189-
dc.identifier.doi10.1038/s41429-020-00385-z-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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