Lipophorin receptor 1 (LpR1) in Drosophila muscle influences life span by regulating mitochondrial aging

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Title
Lipophorin receptor 1 (LpR1) in Drosophila muscle influences life span by regulating mitochondrial aging
Author(s)
Ae-Kyeong Kim; Dae Woo Kwon; Eunbyul Yeom; Kwang-Pyo LeeKi-Sun KwonKweon YuKyu-Sun Lee
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 568, pp. 95-102
Publication Year
2021
Abstract
Sarcopenia is a syndrome characterized by progressive loss of muscle mass and function during aging. Although mitochondrial dysfunction and related metabolic defects precede age-related changes in muscle, their contributions to muscle aging are still not well known. In this study, we used a Drosophila model to investigate the role of lipophorin receptors (LpRs), a Drosophila homologue of the mammalian very low-density lipoprotein receptor (VLDLR), in mitochondrial dynamics and muscle aging. Muscle-specific knockdown of LpR1 or LpR2 resulted in mitochondrial dysfunction and reduced proteostasis, which contributed to muscle aging. Activation of AMP-activated protein kinase (AMPK) ameliorated muscle dysfunction induced by LpR1 knockdown. These results suggest that LpR1/VLDLR is a novel key target that modulates age-dependent lipid remodeling and muscle homeostasis.
Keyword
Drosophila modelSarcopeniaMitochondriaLipoprotein receptorAging
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2021.06.080
Type
Article
Appears in Collections:
Division of Biomaterials Research > Bionanotechnology Research Center > 1. Journal Articles
Division of Research on National Challenges > Aging Research Center > 1. Journal Articles
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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