Angucyclines containing β-D-glucuronic acid from Streptomyces sp. KCB15JA151
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- Title
- Angucyclines containing β-D-glucuronic acid from Streptomyces sp. KCB15JA151
- Author(s)
- Gil Soo Kim; Jun-Pil Jang; Taehoon Oh; Min Cheol Kwon; Byeong San Lee; Jung-Sook Lee; Sung-Kyun Ko; Young-Soo Hong; Jong Seog Ahn; Jae-Hyuk Jang
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry Letters, vol. 48, pp. 128237-128237
- Publication Year
- 2021
- Abstract
- Two angucyclines, pseudonocardones D (1) and E (2), were isolated from Streptomyces sp. KCB15JA151. The planar structure was elucidated by comprehensive spectroscopic analysis. The absolute configuration of the sugar unit was determined based on the basis of coupling constants, ROESY, chemical derivatization and HPLC analysis. The biological activities of compounds 1 and 2 were examined by performing a computational target prediction, which led to tests of the antiestrogenic activity. The result suggested that compound 1 might be an ERα antagonist.
- ISSN
- 0960-894X
- Publisher
- Elsevier
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
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