Angucyclines containing β-D-glucuronic acid from Streptomyces sp. KCB15JA151

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Title
Angucyclines containing β-D-glucuronic acid from Streptomyces sp. KCB15JA151
Author(s)
Gil Soo Kim; Jun-Pil Jang; Taehoon Oh; Min Cheol Kwon; Byeong San Lee; Jung-Sook LeeSung-Kyun KoYoung-Soo HongJong Seog AhnJae-Hyuk Jang
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 48, pp. 128237-128237
Publication Year
2021
Abstract
Two angucyclines, pseudonocardones D (1) and E (2), were isolated from Streptomyces sp. KCB15JA151. The planar structure was elucidated by comprehensive spectroscopic analysis. The absolute configuration of the sugar unit was determined based on the basis of coupling constants, ROESY, chemical derivatization and HPLC analysis. The biological activities of compounds 1 and 2 were examined by performing a computational target prediction, which led to tests of the antiestrogenic activity. The result suggested that compound 1 might be an ERα antagonist.
Keyword
Streptomyces sp.Angucyclineβ-D-Glucuronic acid
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2021.128237
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
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