Ulleunganilines A-C, trichostatin analogues bearing a modified side chain from Streptomyces sp. 13F051

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Title
Ulleunganilines A-C, trichostatin analogues bearing a modified side chain from Streptomyces sp. 13F051
Author(s)
Gui-Ja Hwang; Mina Jang; Sangkeun Son; Byeongsan Lee; Jun-Pil JangJung-Sook LeeSung-Kyun KoYoung-Soo HongJong Seog AhnJae-Hyuk Jang
Bibliographic Citation
Journal of Natural Products, vol. 84, pp. 2420-2426
Publication Year
2021
Abstract
Three new trichostatin analogues, ulleunganilines A-C (1-3), and seven known trichostatins (4-10) were isolated from cultures of Streptomyces sp. 13F051. NMR, UV, and MS data indicated that the planar structures of 1-3 consisted of modified side chains in the trichostatic acid moiety. The absolute configuration of the 2,4-dimethyl-branched carbon chains in 1 and 2 was determined by the PGME method, while the amino acid group in 3 was identified by advanced Marfey's method. Based on the structure of the modified side chains, the origin of 1-3 is proposed. Further experiments indicated that 1 and 3 displayed moderate histone deacetylase inhibitory activity, suggesting that not only the hydroxamate group but also the N,N-dimethyl group were essential for the inhibitory activity.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/acs.jnatprod.1c00324
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
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