The biocatalytic production of 3-hydroxypropionaldehyde and evaluation of its stability

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The biocatalytic production of 3-hydroxypropionaldehyde and evaluation of its stability
Jung-Hyun Ju; Sang Gyu Jeon; K M Lee; Sun-Yeon HeoMinsoo KimChul Ho KimBaek Rock Oh
Bibliographic Citation
Catalysts, vol. 11, no. 10, pp. 1139-1139
Publication Year
3-Hydroxypropionaldehyde (3-HPA, reuterin) is a broad-spectrum natural antimicrobial agent used in the food industry and other fields. The low yield from the industrial production of 3-HPA using Lactobacillus reuteri and the spontaneous conversion of 3-HPA to acrolein have limited its more widespread use. We isolated L. reuteri BR201 as a biocatalyst for 3-HPA production and confirmed the effect of each factor in the two-step procedure for 3-HPA bioconversion. After initial cultivation for 8 h (late exponential phase), this isolate produced 378 mM of 3-HPA in 1 h at a concentration of OD600 nm 100, 30 °C, and an initial glycerol concentration of 500 mM. This is the highest reported biocatalytic yield of 3-HPA from a glycerol aqueous solution without additives. We confirmed that 4 mM of 3-HPA had antimicrobial activity against five pathogens. The degradation of 3-HPA to acrolein was greater at high temperatures, and there was little degradation when 3-HPA was maintained at 4 °C for 4 weeks. Our results may be useful for future applications of 3-HPA.
Lactobacillus reuteri3-hydroxypropionaldehydeReuterinAntibioticStability evaluation
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Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
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