Germinal center-induced immunity is correlated with protection against SARS-CoV-2 reinfection but not lung damage

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Title
Germinal center-induced immunity is correlated with protection against SARS-CoV-2 reinfection but not lung damage
Author(s)
Green Kim; D H Kim; Hanseul Oh; S Bae; J Kwon; M J Kim; E Lee; Eun Ha Hwang; H Jung; Bon-Sang KooSeung Ho BaekPhil Yong KangYou Jung An; J H Park; J H Park; K S Lyoo; Choong-Min Ryu; S H Kim; Jung Joo Hong
Bibliographic Citation
Journal of Infectious Diseases, vol. 224, no. 11, pp. 1861-1872
Publication Year
2021
Abstract
Germinal centers (GCs) elicit protective humoral immunity through a combination of antibody-secreting cells and memory B cells, following pathogen invasion or vaccination. However, the possibility of a GC response inducing protective immunity against reinfection following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unknown. We found GC activity was consistent with seroconversion observed in recovered macaques and humans. Rechallenge with a different clade of virus resulted in significant reduction in replicating virus titers in respiratory tracts in macaques with high GC activity. However, diffuse alveolar damage and increased fibrotic tissue were observed in lungs of reinfected macaques. Our study highlights the importance of GCs developed during natural SARS-CoV-2 infection in managing viral loads in subsequent infections. However, their ability to alleviate lung damage remains to be determined. These results may improve understanding of SARS-CoV-2-induced immune responses, resulting in better coronavirus disease 2019 (COVID-19) diagnosis, treatment, and vaccine development.
Keyword
Germinal centerSARS-CoV-2Viral reinfectionLung damage
ISSN
0022-1899
Publisher
Oxford Univ Press
DOI
http://dx.doi.org/10.1093/infdis/jiab535
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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