Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing

Cited 4 time in scopus
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Title
Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing
Author(s)
J Shin; Jung Ran Noh; D Choe; N Lee; Y Song; S Cho; Eun Jung Kang; Min-Jeong Go; Seok-Kyun Ha; Dong-Ho Chang; Jae-Hoon Kim; Yong-Hoon KimKyoung Shim KimHaiyoung JungMyung Hee KimBong Hyun SungSeung Goo LeeDae Hee LeeByoung Chan KimChul-Ho Lee; B K Cho
Bibliographic Citation
Microbiome, vol. 9, pp. 240-240
Publication Year
2021
Abstract
Background: The gut microbiota is associated with diverse age-related disorders. Several rejuvenation methods, such as probiotic administration and faecal microbiota transplantation, have been applied to alter the gut microbiome and promote healthy ageing. Nevertheless, prolongation of the health span of aged mice by remodelling the gut microbiome remains challenging. Results: Here, we report the changes in gut microbial communities and their functions in mouse models during ageing and three rejuvenation procedures including co-housing, serum-injection and parabiosis. Our results showed that the compositional structure and gene abundance of the intestinal microbiota changed dynamically during the ageing process. Through the three rejuvenation procedures, we observed that the microbial community and intestinal immunity of aged mice were comparable to those of young mice. The results of metagenomic data analysis underscore the importance of the high abundance of Akkermansia and the butyrate biosynthesis pathway in the rejuvenated mouse group. Furthermore, oral administration of Akkermansia sufficiently ameliorated the senescence-related phenotype in the intestinal systems in aged mice and extended the health span, as evidenced by the frailty index and restoration of muscle atrophy. Conclusions: In conclusion, the changes in key microbial communities and their functions during ageing and three rejuvenation procedures, and the increase in the healthy lifespan of aged mice by oral administration of Akkermansia. Our results provide a rationale for developing therapeutic strategies to achieve healthy active ageing. Video abstract.
Keyword
AgeingRejuvenationAkkermansia muciniphilaShotgun metagenomics16s rRNA sequencing
ISSN
2049-2618
Publisher
Springer-BMC
DOI
http://dx.doi.org/10.1186/s40168-021-01189-5
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Biomaterials Research > Synthetic Biology and Bioengineering Research Center > 1. Journal Articles
Division of Biomaterials Research > 1. Journal Articles
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