Thiolactomide: a new homocysteine thiolactone derivative from Streptomyces sp. with neuroprotective activity
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- Title
- Thiolactomide: a new homocysteine thiolactone derivative from Streptomyces sp. with neuroprotective activity
- Author(s)
- Jun-Pil Jang; Min Cheol Kwon; T Nogawa; S Takahashi; H Osada; Jong Seog Ahn; Sung-Kyun Ko; Jae-Hyuk Jang
- Bibliographic Citation
- Journal of Microbiology and Biotechnology, vol. 31, no. 12, pp. 1667-1671
- Publication Year
- 2021
- Abstract
- A new homocysteine thiolactone derivative, thiolactomide (1), was isolated along with a known compound, N-acetyl homocysteine thiolactone (2), from a culture extract of soil-derived Streptomyces sp. RK88-1441. The structures of these compounds were elucidated by detailed NMR and MS spectroscopic analyses with literature study. Biological evaluation studies revealed that both 1 and 2 exhibit neuroprotective activity against 6-hydroxydopamine (6-OHDA) mediated neurotoxicity by blocking generation of hydrogen peroxide in neuroblastoma SH-SY5Y cells.
- Keyword
- ThiolactomideStreptomyces sp.N-acetyl homocysteine thiolactoneNeuroprotective activity6-hydroxydopamine
- ISSN
- 1017-7825
- Publisher
- Korea Soc-Assoc-Inst
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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