Thiolactomide: a new homocysteine thiolactone derivative from Streptomyces sp. with neuroprotective activity

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Title
Thiolactomide: a new homocysteine thiolactone derivative from Streptomyces sp. with neuroprotective activity
Author(s)
Jun-Pil Jang; Min Cheol Kwon; T Nogawa; S Takahashi; H Osada; Jong Seog AhnSung-Kyun KoJae-Hyuk Jang
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 31, no. 12, pp. 1667-1671
Publication Year
2021
Abstract
A new homocysteine thiolactone derivative, thiolactomide (1), was isolated along with a known compound, N-acetyl homocysteine thiolactone (2), from a culture extract of soil-derived Streptomyces sp. RK88-1441. The structures of these compounds were elucidated by detailed NMR and MS spectroscopic analyses with literature study. Biological evaluation studies revealed that both 1 and 2 exhibit neuroprotective activity against 6-hydroxydopamine (6-OHDA) mediated neurotoxicity by blocking generation of hydrogen peroxide in neuroblastoma SH-SY5Y cells.
Keyword
ThiolactomideStreptomyces sp.N-acetyl homocysteine thiolactoneNeuroprotective activity6-hydroxydopamine
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.4014/jmb.2108.08015
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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