Light-stimulated carbon dot hydrogel: targeting and clearing infectious bacteria in vivo

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Title
Light-stimulated carbon dot hydrogel: targeting and clearing infectious bacteria in vivo
Author(s)
C H Lee; Seuk Young Song; Y J Chung; Eun Kyoung Choi; J Jang; D H Lee; Hae Dong Kim; Dong Uk Kim; C B Park
Bibliographic Citation
ACS Applied Bio Materials, vol. 5, no. 2, pp. 761-770
Publication Year
2022
Abstract
Infectious bacteria evolve fast into resistance to conventional antimicrobial agents, whereas treatments for drug resistance bacteria progress more slowly. Here, we report a universally applicable photoactivated antimicrobial modality through light-responsive carbon dot-embedding soft hyaluronic acid hydrogel (CDgel). Because of the innate nature of the infectious bacteria that produce hyaluronidase, applied hyaluronic acid-based CDgel breaks down via bacteria and releases carbon dots (CDs) into the infectious sites. The released CDs possess photodynamic capabilities under light irradiation, inducing 1O2 generation and growth inhibition of the infectious bacteria, S. aureus and E. coli (∼99% and ∼97%, respectively), in vitro. In particular, these photodynamic effects of CDs from CDgel have been shown to accelerate the healing of infected wounds in vivo, showing a higher wound regeneration rate as compared to that of untreated wounds. Our work demonstrates that the biocompatible and shape-controllable CDgel possesses therapeutic potential as a treatment modality for the light-driven control of drug-resistant bacterial infections.
Keyword
Carbon dotPhotoablationHydrogelInfectious diseaseAntibacterialWound healing
ISSN
2576-6422
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/acsabm.1c01157
Type
Article
Appears in Collections:
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
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