Light-stimulated carbon dot hydrogel: targeting and clearing infectious bacteria in vivo

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Light-stimulated carbon dot hydrogel: targeting and clearing infectious bacteria in vivo
C H Lee; Seuk Young Song; Y J Chung; Eun Kyoung Choi; J Jang; D H Lee; Hae Dong Kim; Dong Uk Kim; C B Park
Bibliographic Citation
ACS Applied Bio Materials, vol. 5, no. 2, pp. 761-770
Publication Year
Infectious bacteria evolve fast into resistance to conventional antimicrobial agents, whereas treatments for drug resistance bacteria progress more slowly. Here, we report a universally applicable photoactivated antimicrobial modality through light-responsive carbon dot-embedding soft hyaluronic acid hydrogel (CDgel). Because of the innate nature of the infectious bacteria that produce hyaluronidase, applied hyaluronic acid-based CDgel breaks down via bacteria and releases carbon dots (CDs) into the infectious sites. The released CDs possess photodynamic capabilities under light irradiation, inducing 1O2 generation and growth inhibition of the infectious bacteria, S. aureus and E. coli (∼99% and ∼97%, respectively), in vitro. In particular, these photodynamic effects of CDs from CDgel have been shown to accelerate the healing of infected wounds in vivo, showing a higher wound regeneration rate as compared to that of untreated wounds. Our work demonstrates that the biocompatible and shape-controllable CDgel possesses therapeutic potential as a treatment modality for the light-driven control of drug-resistant bacterial infections.
Carbon dotPhotoablationHydrogelInfectious diseaseAntibacterialWound healing
Amer Chem Soc
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Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
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