RK-270D and E, oxindole derivatives from Streptomyces sp. with anti-angiogenic activity

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Title
RK-270D and E, oxindole derivatives from Streptomyces sp. with anti-angiogenic activity
Author(s)
Jun-Pil Jang; Mina Jang; T Nogawa; S Takahashi; H Osada; Jong Seog AhnSung-Kyun KoJae-Hyuk Jang
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 32, no. 3, pp. 302-306
Publication Year
2022
Abstract
A chemical investigation of a culture extract from Streptomyces sp. RK85-270 led to the isolation and characterization of two new oxindoles, RK-270D (1) and E (2). The structure of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and HRESIMS experiments. Compound 1 exhibited anti-angiogenic activities against human umbilical vein endothelial cells (HUVECs) without cytotoxicity. Results of Western blot analysis revealed that 1 inhibits VEGF-induced angiogenesis in the HUVECs via VEGFR2/ p38 MAPK-mediated pathway.
Keyword
OxindoleStreptomyces sp.Structural elucidationAnti-angiogenic activity
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.4014/jmb.2110.10039
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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