Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA151

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Title
Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA151
Author(s)
Jun-Pil Jang; G S Kim; Tae Hoon Oh; Beomcheol Park; Minhee Kim; Gwi Ja Hwnag; Hyeok Won LeeJin Gyeom LeeYoung-Soo Hong; Jong Seog Ahn; Sung-Kyun KoJae-Hyuk Jang
Bibliographic Citation
RSC Advances, vol. 12, pp. 22360-22366
Publication Year
2022
Abstract
Two new polyketide glycosides jejuketomycins A (1) and B (2), were isolated from a culture of Streptomyces sp. KCB15JA151. Their chemical structures including the absolute configurations were determined by detailed analyses of the NMR and HRMS data and ECD calculations and spectral data. Compounds 1 and 2 possess an unusual 6/6/8 tricyclic ring system. Biological evaluation with the wound healing assay and time-lapse cell tracking analysis revealed that compounds 1 and 2 have significant inhibitory activities against cancer cell migration with low cytotoxicity.
ISSN
2046-2069
Publisher
Royal Soc Chem
DOI
http://dx.doi.org/10.1039/d2ra04039e
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Division of Bio Technology Innovation > BioProcess Engineering Center > 1. Journal Articles
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