Regulatory effects of Lycium barbarum extract and isolated scopoletin on atopic dermatitis-like skin inflammation

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Title
Regulatory effects of Lycium barbarum extract and isolated scopoletin on atopic dermatitis-like skin inflammation
Author(s)
Seon Gyeong Bak; Hyung-Jin Lim; Yeong-Seon Won; Soyoung Lee; S H Cheong; S J Lee; E Y Bae; Seung Woong LeeSeung Jae LeeMun Chual Rho
Bibliographic Citation
Biomed Research International, vol. 2022, pp. 2475699-2475699
Publication Year
2022
Abstract
Lycium barbarum and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4-dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF-α)/interferon gamma (IFN-γ). The inhibitory activity of L. barbarum EtOH extract (LBE) and scopoletin on proinflammatory cytokines and chemokines was investigated. In the DNCB-induced animal model, oral administration of LBE inhibited skin lesions and proinflammatory cytokines and chemokines and showed inhibitory effects in vitro. Additionally, as a result of examining the efficacy of scopoletin isolated from L. barbarum, scopoletin in HaCaT cells showed inhibitory effects on proinflammatory cytokines and chemokines. It shows promise in the treatment of chronic skin diseases.
ISSN
2314-6133
Publisher
Hindawi Ltd
DOI
http://dx.doi.org/10.1155/2022/2475699
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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