Ulleungdolin, a Polyketide-Peptide Hybrid Bearing a 2,4-Di-O-methyl-β-d-antiarose from Streptomyces sp. 13F051 Co-cultured with Leohumicola minima 15S071

Cited 0 time in scopus
Metadata Downloads
Title
Ulleungdolin, a Polyketide-Peptide Hybrid Bearing a 2,4-Di-O-methyl-β-d-antiarose from Streptomyces sp. 13F051 Co-cultured with Leohumicola minima 15S071
Author(s)
Gwi Ja Hwnag; Mina Jang; Sangkeun Son; Gil Soo Kim; Byeongsan Lee; Kyung Taek Heo; G J Kim; H Choi; J S Hur; Jun-Pil JangSung-Kyun KoYoung-Soo HongJong Seog AhnJae-Hyuk Jang
Bibliographic Citation
Journal of Natural Products, vol. 85, no. 10, pp. 2445-2453
Publication Year
2022
Abstract
A new secondary metabolite, ulleungdolin (1), was isolated from the co-culture of an actinomycete, Streptomyces sp. 13F051, and a fungus, Leohumicola minima 15S071. Based on the NMR, UV, and MS data, it was deduced that the planar structure of 1 comprised an isoindolinone (IsoID) with an octanoic acid, a tripeptide, and a sugar. The tripeptide has the unprecedented amino acids norcoronamic acid, 3-hydroxy-glutamine, and 4-hydroxy-phenylglycine and is linked by a C-N bond with IsoID. The absolute configurations were determined by chemical derivatization, extensive spectroscopic methods, and electronic circular dichroism calculations and supported by bioinformatic analyses. Bioactivity evaluation studies indicated that 1 had an antimigration effect on MDA-MB-231 breast cancer cells.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/acs.jnatprod.2c00682
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.