Determination of the unilaterally damaged region may depend on the asymmetry of carotid blood flow velocity in hemiparkinsonian monkey: a pilot study = 편측 파킨슨병 원숭이 모델은 경동맥 혈류속도의 비대칭성에 따라 손상영역이 달라질 수 있다

Abstract

The hemiparkinsonian nonhuman primate model induced by unilateral injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the carotid artery is used to study Parkinson’s disease. However, there have been no studies that the contralateral distribution of MPTP via the cerebral collateral circulation is provided by both the circle of Willis (CoW) and connections of the carotid artery. To investigate whether MPTP-induced unilaterally damaged regions were determined by asymmetrical cerebral blood 7ow, the di8erential asymmetric damage of striatal subregions, and examined structural asymmetries in a circle of Willis, and blood 7ow velocity of the common carotid artery were observed in three monkeys that were infused with MPTP through the left internal carotid artery. Lower 7ow velocity in the ipsilateral common carotid artery and a higher ratio of ipsilateral middle cerebral artery diameter to anterior cerebral artery diameter resulted in unilateral damage. Additionally, the unilateral damaged monkey observed the apomorphine-induced contralateral rotation behavior and the temporary increase of plasma RANTES. Contrastively, higher 7ow velocity in the ipsilateral common carotid artery was observed in the bilateral damaged monkey. It is suggested that asymmetry of blood 7ow velocity and structural asymmetry of the circle of Willis should be taken into consideration when establishing more e<cient hemiparkinsonian nonhuman primate models.