Determination of the unilaterally damaged region may depend on the asymmetry of carotid blood flow velocity in hemiparkinsonian monkey: a pilot study = 편측 파킨슨병 원숭이 모델은 경동맥 혈류속도의 비대칭성에 따라 손상영역이 달라질 수 있다

Cited 0 time in scopus
Metadata Downloads
Title
Determination of the unilaterally damaged region may depend on the asymmetry of carotid blood flow velocity in hemiparkinsonian monkey: a pilot study = 편측 파킨슨병 원숭이 모델은 경동맥 혈류속도의 비대칭성에 따라 손상영역이 달라질 수 있다
Author(s)
Jincheol Seo; Kyung Seob LimChang-Yeop JeonSeung Ho Baek; Hyeon-Gu Yeo; Won Seok ChoiSung Hyun ParkKang Jin Jeong; Jinyoung Won; Keonwoo Kim; Junghyung Park; Jiyeon Cho; Jung Bae Seong; Minji Kim; Yu Gyeong Kim; Jae Won Huh; S Kim; Y H Lim; H W Park; H M Tak; M S Heo; J W Choi; S H Paek; Youngjeon Lee
Bibliographic Citation
Parkinsons Disease, vol. 2022, pp. 4382145-4382145
Publication Year
2022
Abstract
The hemiparkinsonian nonhuman primate model induced by unilateral injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the carotid artery is used to study Parkinson’s disease. However, there have been no studies that the contralateral distribution of MPTP via the cerebral collateral circulation is provided by both the circle of Willis (CoW) and connections of the carotid artery. To investigate whether MPTP-induced unilaterally damaged regions were determined by asymmetrical cerebral blood 7ow, the di8erential asymmetric damage of striatal subregions, and examined structural asymmetries in a circle of Willis, and blood 7ow velocity of the common carotid artery were observed in three monkeys that were infused with MPTP through the left internal carotid artery. Lower 7ow velocity in the ipsilateral common carotid artery and a higher ratio of ipsilateral middle cerebral artery diameter to anterior cerebral artery diameter resulted in unilateral damage. Additionally, the unilateral damaged monkey observed the apomorphine-induced contralateral rotation behavior and the temporary increase of plasma RANTES. Contrastively, higher 7ow velocity in the ipsilateral common carotid artery was observed in the bilateral damaged monkey. It is suggested that asymmetry of blood 7ow velocity and structural asymmetry of the circle of Willis should be taken into consideration when establishing more e
ISSN
2090-8083
Publisher
Hindawi
DOI
http://dx.doi.org/10.1155/2022/4382145
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.