Enhanced production of shikonin by Lithospermum erythrorhizon cells immobilized in polyurethane foam matrices

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Title
Enhanced production of shikonin by Lithospermum erythrorhizon cells immobilized in polyurethane foam matrices
Author(s)
Young Hoon Park; Weon Taek Seo; Jang Ryol Liu
Bibliographic Citation
Journal of Fermentation Bioengineering, vol. 70, no. 5, pp. 317-321
Publication Year
1990
Abstract
Production of shikonin by Lithospermum erythrorhizon cells immobilized in polyurethane foam matrices was investigated. The cells were effectively entrapped inside the polymer matrices prepared in a cubic form with a lateral length of 0.5 cm. They proliferated further by incubation and resulted in immobilized and resulted in immobilized polymer foam cubes which were fully packed with cell aggregates. Shikonin production was observed to increase significantly when the immobilized cells were used. It was excreted by the cells and directly adsorbed, by hydrophobic interaction, to the polymer site. The product could be recovered, after the cells were separated, by direct solvent extraction from the shikonin-adsorbed polyurethane matrices. It is more interesting to note that a single-stage culture with immobilized L. erythrorhizon cells yielded higher shikonin productivity than the conventional two-stage culture system, which is considered to be of practical importance for industrial applications.
Keyword
shikoninimmobilized cellplant celllithospermum erythrorhizon
ISSN
0385-6380
Publisher
Soc Bioscience Bioengineering Japan
DOI
http://dx.doi.org/10.1016/0922-338X(90)90141-I
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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