Conductive thread-based immunosensor for pandemic influenza A (H1N1) virus detection

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Conductive thread-based immunosensor for pandemic influenza A (H1N1) virus detection
Seong Uk Son; Soojin Jang; Jaewoo Lim; Seung Beom Seo; Taejoon KangJuyeon Jung; Seo Yeong Oh; S W Yoon; D Yong; J Lee; Eun Kyung Lim
Bibliographic Citation
ACS Applied Materials & Interfaces, vol. 15, no. 6, pp. 7759-7766
Publication Year
Infectious agents such as viruses pose significant threats to human health, being transmitted via direct contact as well as airborne transmission without direct contact, thus requiring rapid detection to prevent the spread of infectious diseases. In this study, we developed a conductive thread-based immunosensor (CT-IS), a biosensor to easily detect the presence of airborne viruses. CT-IS utilizes an antibody that specifically recognizes the HA protein of the pandemic influenza A (pH1N1) virus, which is incorporated into the conductive thread. The antigen-antibody interaction results in increased strain on the conductive thread in the presence of the pH1N1 virus, resulting in increased electrical resistance of the CT-IS. We evaluated the performance of this sensor using the HA protein and the pH1N1 virus, in addition to samples from patients infected with the pH1N1 virus. We observed a significant change in resistance in the pH1N1-infected patient samples (positive: n = 11, negative: n = 9), whereas negligible change was observed in the control samples (patients not infected with the pH1N1 virus; negative). Hence, the CT-IS is a lightweight fiber-type sensor that can be used as a wearable biosensor by combining it with textiles, to detect the pH1N1 virus in a person's vicinity.
Respiratory infectionpH1N1 virusConductive threadElectric immunosensorPoint-of-care detection
Amer Chem Soc
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Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
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