Glucose-limited fed-batch culture of Escherichia coli for production of recombinant human interleukin-2 with the DO-stat method

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Title
Glucose-limited fed-batch culture of Escherichia coli for production of recombinant human interleukin-2 with the DO-stat method
Author(s)
Dong Jin Seo; Bong Hyun Chung; Young Bo Hwang; Young Hoon Park
Bibliographic Citation
Journal of Fermentation Bioengineering, vol. 74, no. 3, pp. 196-198
Publication Year
1992
Abstract
Fed-batch culture employing the DO-stat method was carried out to produce recombinant human interleukin-2 in Escherichia coli. The concentration of interleukin-2 and final cell density in the fed-batch culture were 1.02 g/l and 60 OD (optical density), respectively. This represents a significant improvement in interleukin-2 production and final cell density over the equivalent values of batch fermentation.
ISSN
0385-6380
Publisher
Soc Bioscience Bioengineering Japan
DOI
http://dx.doi.org/10.1016/0922-338X(92)90085-9
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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