Antitumoral macrolide antibiotics from Streptomyces sp. Ba16 = 방선균에서 분리한 macrolide 계 항암활성물질

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Title
Antitumoral macrolide antibiotics from Streptomyces sp. Ba16 = 방선균에서 분리한 macrolide 계 항암활성물질
Author(s)
Hang Sub Kim; Se Eun Kim; Sung Woo Lee; Hee-Jae Bang; Young Ho Kim; Jung Joon Lee
Bibliographic Citation
Korean Journal of (Applied) Microbiology & Biotechnology, vol. 22, no. 4, pp. 368-372
Publication Year
1994
Abstract
Three more unusual macrolides in addition to concnamycin B were isolated from the mycelium of Streptomyces sp. strain Bal6. These four compounds showed a potent cytotoxity to hunian cancer cell lines, SNU-1 (stomach cancer cell line), SNU-354 (liver cancer cell line), MCF- 7 (breast cancer cell line) and KB-3-1 (oral epidermoid carcinoma cell line). Interestingly, these compounds confered slight differential cytotoxity on RHEK-1, a human epidermal keratinocyte cell line immotalized by AD12-SV40 hybrid virus and RHEK-1/pSV2 ras which was resulted from H-ras transfomation of RHEK-1. These compounds were determined to be concanamycin A, conca- namycin E and 0-methyl concanamycin B by NMR and other spectral analysis.
Keyword
Complement systemanti-complementary polysaccharideFlammulina velutipesaction mode
ISSN
0257-2389
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
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