Direct exposure to 2,3,7,8-tetrachlodibenzo-p-dioxin(TCDD) increases infectivity of human erythrocytes to a malarial parasite

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Title
Direct exposure to 2,3,7,8-tetrachlodibenzo-p-dioxin(TCDD) increases infectivity of human erythrocytes to a malarial parasite
Author(s)
Hwan Mook Kim; In Pyo Choi; M P Holsapple
Bibliographic Citation
Life Sciences, vol. 54, no. 12, pp. 215-220
Publication Year
1994
Abstract
Direct exposure to 10 nM 2,3,7,8-TCDD caused a 75% increase and a 2-fold increase in the infectivity of isolated human erythrocytes to P. falciparum after 48 hours when the parasites were in an unsynchronized or synchronized state of growth, respectively. Treatment of human erythrocytes with 10 μM sodium orthovanadate (NaOV), an inhibitor of plasma membrane Ca-ATPase and phosphotyrosine phosphatase, decreased parasitemia by 30%. Co-treatment of RBCs with TCDD and NaOV completely blocked the TCDD-induced increase in parasitemia. Because erythrocytes are anucleated, these results are discussed as evidence for biochemical changes by TCDD without requiring the activation of gene products.
ISSN
0024-3205
Publisher
Elsevier
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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