Isolation of modulators for multidrug resistance from the fruits of Evodia officinalis = 약용식물 오수유로부터 다제약제 내성 조절물질의 분리

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Title
Isolation of modulators for multidrug resistance from the fruits of Evodia officinalis = 약용식물 오수유로부터 다제약제 내성 조절물질의 분리
Author(s)
Sung Woo Lee; Bang Yeon Hwang; Se Eun Kim; Hwan Mook Kim; Young Ho Kim; Kyong Soon Lee; Jung Joon Lee; Jai-Seup Ro
Bibliographic Citation
Korean Journal of Pharmacognosy, vol. 26, no. 4, pp. 344-348
Publication Year
1995
Abstract
Preliminary screening test of modulators for multidrug resistance with 400 medicinal plants was carried out by using human multidrug resistance cell line, KB-V1. Among active medicinal plants, the unripe fruits of Evodia officinalis showed a potent modulating activity of MDR. From MeOH extract of this plant, we isolated two indole alkaloids, rutaecarpine (1) and evodiamine (2), by repeated silicagel column chromatography. Rutaecarpine increased the cytotoxicities of vinblastine and taxol against multidrug resistance cells, but evodiamine showed no modulating activity in spite of its potent cytotoxic activities.
Keyword
cytotoxic activitiesevodia officinalisevodiaminemultidrug resistancerutaecarpine
ISSN
0253-3073
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
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