Agastaquinone from the root of Agastache rugosa and cytotoxicity

Cited 26 time in scopus
Metadata Downloads
Title
Agastaquinone from the root of Agastache rugosa and cytotoxicity
Author(s)
Hyeong Kyu Lee; Sei Ryang Oh; JI Kim; CO Lee
Bibliographic Citation
Journal of Natural Products, vol. 58, no. 11, pp. 1721-1724
Publication Year
1995
Abstract
Investigation of the cytotoxic constituents of a two-sponge association (Pwrillartra sp. and Jaspis sp.) led to the isolation ofpectenotoxin I1 [I] and psammaplin A as the active compounds. In an in vitro cell culture assay, 1 displayed very potent cytotoxic activities against human lung (A-549), colon (HT-29), and breast (MCF-7) cancer cell lines. Pectenotoxin I1 also exhibited selective cytotoxicity against several cell lines representing ovarian, renal, lung, colon, CNS, melanoma, and breast cancer, with differences in LC,, values between sensitive and resistant cell lines of 100-fold or more.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np50125a011
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.