Gradual accumulation of mutations in precore core region of HBV in patients with chronic active hepatitis : implications of clustering changes in a small region of the HBV core region

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Title
Gradual accumulation of mutations in precore core region of HBV in patients with chronic active hepatitis : implications of clustering changes in a small region of the HBV core region
Author(s)
Gang Min Hur; Yoon Ik Lee; Dong Jin Suh; Jae Heun Lee; Young Ik Lee
Bibliographic Citation
Journal of Medical Virology, vol. 48, no. 1, pp. 38-46
Publication Year
1996
Abstract
The sequence in the precore and core region of the hepatitis B virus (HBV) genome in the serum of five chronic active hepatitis patients at four different stages in each individual were studied by polymerase chain reaction and DNA sequencing to determine the prevalence and type of precore and core mutants in each chronic active hepatitis (CAH) patient. Gradual changes of the virus genome in each CAH patient in precore and core regions were identified. Except for the virus from one patient, the mutant viruses showed gradual changes of genome sequences, which resulted in the generation of stop codons at the precore and core region, causing the association of active hepatitis in each patient even in the presence of anti-HBe. Mutational hot spots in the core region, which includes a clustering of changes in a small region of 14 amino acids (codons 84-97 from the start of the core gene) were found in all patients. This region of mutational hot spots in the core might be a major target of cytotoxic T lymphocytes (CTL), which has evolved under the pressure of immune selections, and these mutants might play a important role in the pathogenesis of viral hepatitis.
Keyword
Cytotoxic T lymphocytes (CTL)Hepatitis variationPolymerase chain reactionPrecoreicore region (pre-C/C)Variation
ISSN
0146-6615
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/(SICI)1096-9071(199601)48:1<38::AID-JMV6>3.0.CO;2-M
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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