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- Title
- Bestatin analogue from Streptomyces neyagawaensis SL-387
- Author(s)
- Myung Chul Chung; Ho Jae Lee; Hyo Kon Chun; Choong Hwan Lee; Su-Il Kim; Yung Hee Kho
- Bibliographic Citation
- Bioscience Biotechnology and Biochemistry, vol. 60, no. 5, pp. 898-900
- Publication Year
- 1996
- Abstract
- A bestatin analogue, (2S,3R)-3-amino-2-hydroxy-4- phenylbutanoyl-L- valine (AHPA-Val), from the culture filtrate of Streptomyces neyagawaensis SL-387 was obtained in a chemically defined medium containing DL- 3-amino-3- phenylpropionic acid. AHPA-Val was 6 times (IC50=1.2 μg/ml) as strong as bestatin (IC50=7.0 μg/ml) against porcine kidney microsomal aminopeptidase N, and 4 times (5.6 μg/ml) as strong as bestatin (IC50= 20.7 μg/ml) against amino-peptidase N of human metastatic fibrosarcoma HT1080. To the best of our knowledge, this is the first report on the microbial production of AHPA-Val.
- Keyword
- aminopeptidase Nbestatin analogueinhibitorbestatinMR 387Astreptomycesstreptomyces neyagawaensis
- ISSN
- 0916-8451
- Publisher
- T&F (Taylor & Francis)
- Type
- Article
- Appears in Collections:
- Division of Bio Technology Innovation > SME Support Center > 1. Journal Articles
- Files in This Item:
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