GERI-BP002-A, novel inhibitor of Acyl-CoA : cholesterol acyltransferase produced by Aspergillus fumigatus F93

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Title
GERI-BP002-A, novel inhibitor of Acyl-CoA : cholesterol acyltransferase produced by Aspergillus fumigatus F93
Author(s)
Young Kook Kim; Hyun Woo Lee; Kwang Hee Son; Byoung-Mog Kwon; Tae Sook Jeong; Dong-Heui Lee; Jongheon Shin; Youngwan Seo; Sung Uk Kim; Song Hae Bok
Bibliographic Citation
Journal of Antibiotics, vol. 49, no. 1, pp. 31-36
Publication Year
1996
Abstract
A new inhibitor of acyl-CoA : cholesterol acyltransfcrase (ACAT), designated GERI-BP002-A, was isolated from the culture broth of Aspergillus fumigalus F93 by acetone extraction, EtOAc extraction, SiO2 column chromatography and reverse phase HPLC. Spectroscopic analyses of the compound identified bis (2-hydroxy-3-tert-butyl-5-methylphenyl) methane as the structure and its molecular weight and formula to be 340 and C23H32O2, respectively. GERI-BP002-A inhibited ACAT activity by 50% at the concentration of 50 μM in an enzyme assay system using rat liver microsomes.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.7164/antibiotics.49.31
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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