Reversal activity of multidrug-resistance by Hatomarubigins = Hatomarubigin의 다제내성극복 활성

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Title
Reversal activity of multidrug-resistance by Hatomarubigins = Hatomarubigin의 다제내성극복 활성
Author(s)
하상철
Bibliographic Citation
Korean Journal of (Applied) Microbiology & Biotechnology, vol. 24, no. 2, pp. 242-246
Publication Year
1996
Abstract
Hatomarubigins inhibited the growth of various cancer cell lines including multidrug-resistance cells. Hatomarubigins were found to potentiate the colchicine- and vinblastine-induced cytotoxicity against KB-C2 cell, but not the adriamycin-induced cytotoxicity against KB-C2 cells. Hatomarubigins didn't affect the sensitive KB cells. These results suggest that hatomarubigins are specific potentiators of colchicine. Among four hatomarubigins, hatomarubigin A showed the highest synergestic effect on colchine-induced cytotoxicity. Similar effect of hatomarubigin A was found against V79/ADM cells.
Keyword
colchicinehatomarubiginsKB-C2 cellmultidrug-resistance cells
ISSN
0257-2389
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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