In vitro anticomplementary activity of phenylpropanoids from Agastache rugosa

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Title
In vitro anticomplementary activity of phenylpropanoids from Agastache rugosa
Author(s)
Sei Ryang Oh; Keun Young Jung; Hyeong Kyu Lee
Bibliographic Citation
Korean Journal of Pharmacognosy, vol. 27, no. 1, pp. 20-25
Publication Year
1996
Abstract
In searching for anticomplementary compounds, three phenylpropanoids were isolated from the roots of Agastache rugosa and identified as rosmarinic acid (RA), rosmarinic acid methyl ester (RAM) and caffeic acid methyl ester (CAM) by NMR analyses. RA and RAM exhibited strong inhibitory activity on both the classical pathway (CP) and the alternative pathway (AP) of the complement system, in vitro, but CAM did far less than RA and RAM. RAM-MI~-M5, the methylated derivatives from the RAM, showed that the inhibitory activity was decreased in inverse proportion to the number of methylated groups and RAM-M 2~-M4, the isomers of two methylated hydroxyl groups, exhibited different inhibition activity.
Keyword
caffeic acid methyl esterrosmarinic acidrosmarinic acid methyl esteranticomplement activityagastache rugosa
ISSN
0253-3073
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
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