In vitro anticomplementary activity of phenylpropanoids from Agastache rugosa

Cited 0 time in scopus
Metadata Downloads
In vitro anticomplementary activity of phenylpropanoids from Agastache rugosa
Sei Ryang Oh; Keun Young Jung; Hyeong Kyu Lee
Bibliographic Citation
Korean Journal of Pharmacognosy, vol. 27, no. 1, pp. 20-25
Publication Year
In searching for anticomplementary compounds, three phenylpropanoids were isolated from the roots of Agastache rugosa and identified as rosmarinic acid (RA), rosmarinic acid methyl ester (RAM) and caffeic acid methyl ester (CAM) by NMR analyses. RA and RAM exhibited strong inhibitory activity on both the classical pathway (CP) and the alternative pathway (AP) of the complement system, in vitro, but CAM did far less than RA and RAM. RAM-MI~-M5, the methylated derivatives from the RAM, showed that the inhibitory activity was decreased in inverse proportion to the number of methylated groups and RAM-M 2~-M4, the isomers of two methylated hydroxyl groups, exhibited different inhibition activity.
caffeic acid methyl esterrosmarinic acidrosmarinic acid methyl esteranticomplement activityagastache rugosa
Korea Soc-Assoc-Inst
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.