Isolation and characterization of antifungal compound produced by Aspergillus candidus F1484 = Aspergillus candidus F1484 균주가 생산하는 항진균 화합물의 분리 및 특성

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Title
Isolation and characterization of antifungal compound produced by Aspergillus candidus F1484 = Aspergillus candidus F1484 균주가 생산하는 항진균 화합물의 분리 및 특성
Author(s)
Sung Uk Kim; So Young Lee; Sung Kyu Kim; Kwang Hee Son; Young Kook Kim; S S Moon; Song Hae Bok
Bibliographic Citation
Korean Journal of (Applied) Microbiology & Biotechnology, vol. 24, no. 5, pp. 574-578
Publication Year
1996
Abstract
In the course of screening for the antifungal compounds against Candida albicans, an antifungal compound (F1480) was isolated from the culture broth of Aspergillus candidus F1484. Isolation and purification of compound F1484 were performed using ethyl acetate extraction, silica gel column chromatography, ODS column chromatography, and preparative HPLC. The structure of compound F1484 was determined by the spectroscopic analyses of EI-MS, 13C-, 1H-NMR, DEPT, HMQC, and HMBC. This compound appeared to have a structure of antifungal agent, chloroflavonin. In addition to antifungal activities against the yeast phase of Candida species, compound F1484 showed cytotoxic effect against various human tumor cell lines.
Keyword
antifungal activityC. albicanscytotoxicitydimorphism
ISSN
0257-2389
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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