Production of D-β-hydroxyisobutyric acid from isobutyric acid by Candida rugosa

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Title
Production of D-β-hydroxyisobutyric acid from isobutyric acid by Candida rugosa
Author(s)
In Young Lee; Won Kyoung Hong; Young Bo Hwang; Chul Ho Kim; Eui Sung Choi; Sang Ki Rhee; Young Hoon Park
Bibliographic Citation
Journal of Fermentation Bioengineering, vol. 81, no. 1, pp. 79-82
Publication Year
1996
Abstract
Production of D-β-hydroxyisobutyric acid (D-HIBA) from isobutyric acid (IBA) was investigated using Candida rugosa IFO 0750. Cell growth and D-HIBA production decreased as the substrate concentration increased. A considerable degradation of D-HIBA was observed when the substrate, IBA, was depleted in the medium. Specific production rate of D-HIBA increased as glucose concentration decreased, while the conversion yield of IBA to D-HIBA showed an opposite trend. With a controlled feeding of IBA and glucose, a high titer of D-HIBA (100 g/l) could be obtained by a fed-batch cultivation of Candida rugosa.
Keyword
candida rugosaD-β-hydroxyisobutyric acidproduction
ISSN
0385-6380
Publisher
Soc Bioscience Bioengineering Japan
DOI
http://dx.doi.org/10.1016/0922-338X(96)83126-6
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
Division of Bio Technology Innovation > BioProcess Engineering Center > 1. Journal Articles
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