Open Access@KRIBBDivision of A.I. & Biomedical ResearchMetabolic Regulation Research Center1. Journal Articles
When gut fibroblasts feed epithelial cells to death
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- Title
- When gut fibroblasts feed epithelial cells to death
- Author(s)
- Jong Woo Kim; Byeong Jun Jeong; Eun-Woo Lee
- Bibliographic Citation
- Nature Metabolism, vol. 7, pp. 1307-1309
- Publication Year
- 2025
- Abstract
- Epithelial cell death driven by oxidative stress is a hallmark of inflammatory bowel disease (IBD), but the upstream triggers are unclear. A new study reveals that fibroblast-derived lipids enriched with polyunsaturated fatty acids induce epithelial ferroptosis. Genetic or pharmacological inhibition of fibroblast ACSL4 alleviates intestinal inflammation and injury in IBD models.
- ISSN
- 2522-5812
- Publisher
- Springer-Nature Pub Group
- Full Text Link
- http://dx.doi.org/10.1038/s42255-025-01315-9
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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