Investigation of Korean plant extracts for potential phytotherapeutic agents against B-virus hepatitis

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Title
Investigation of Korean plant extracts for potential phytotherapeutic agents against B-virus hepatitis
Author(s)
Tae-Ho Jung; J. C. Kim; M.K. Kim; S. C. Choi; S. L. Kim; J. M. Chung; I. S. Lee; Seung Ho Kim; Kyung Soo Hahm; I. P. Lee
Bibliographic Citation
Phytotherapy Research, vol. 9, no. 6, pp. 429-434
Publication Year
1995
Abstract
The present study was undertaken to identify potential phytotherapeutic agents among the aqueous extracts of 151 herbal medicinal plants of Korea. Extracts were assayed for (1) binding potency to hepatitis B-virus surface antigen (HBsAg), and (2) inhibition of serum hepatitis B-virus DNA polymerase activity. of the 151 aqueous plant extracts tested 33 demonstrated a positive precipitation reaction with HBsAg+ serum, and 15 of these specifically bound HBsAg in serum as well as recombinant HBsAg (Hepavax). Nine extracts competitively inhibited >80% of anti-HBsAg antibody binding to Hepavax® HBsAg. Furthermore, nine of these 15 plant extracts also exhibited greater than 25%-50% inhibition of hepatitis B-virus DNA polymerase activity, and also significantly stimulated production of the potent cytokine, tumour necrosis factor (TNF). None of the extract concentrations used altered liver function parameters of normal rats.
Keyword
HBV DNA polymeraseHuman hepatitis B-virus (HBV)Korean medicinal plantsTumour necrosis factor
ISSN
0951-418X
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/ptr.2650090609
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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